Observations of the Influence of Chondroitin Sulphate on the Rate of Bone Repair

promoted by demineralised bone, reconstituted acid-soluble collagen, and gelatin in the form of Gelfoam.t The index employed was the rate of bone repair in a standard defect produced in the calvaria of rats. These investigations are an extension of our earlier studies in which we observed that, under certain conditions, chondroitin sulphate would restore the mineralising properties of demineralised bone (predominantly acid-insoluble collagen) in vitro with inorganic media, and in vito when transplanted under the skin of rats (Burger, Lavine, Deane and Sobel 1957; Sobel, Burger and Deane 1957; Sobel, Burger and Lavine 1960; Sobel, Burgerand Nobel 1960, Sobel 1961).